Recombinant Human CAMLG, His-tagged

Cat.No. : CAMLG-15870H
Product Overview : Recombinant human CAMLG protein, fused to His tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
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Species : Human
Source : E.coli
Tag : His
Protein Length : 1-189aa
Description : The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. CAMLG functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol
Molecular Mass : 23.2 kDa (212aa), confirmed by MALDI-TOF
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSMESMAVA TDGGERPGVP AGSGLSASQR RAELRRRKLL MNSEQRINRI MGFHRPGSGA EEESQTKSKQ QDSDKLNSLS VPSVSKRVVL GDSVSTGTTD QQGGVAEVKG TQLGDKLDSF IKPPECSSDV NLELRQRNRG DLTADSVQRG SRHGLEQYLS RFEEAMKLRK QLISEKPSQE DGNTTEEFDS FR
Purity : >85% by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at 4°C short term. For long term storage, aliquot and store at at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration : 0.5 mg/ml (determined by Bradford assay)
Gene Name CAMLG calcium modulating ligand [ Homo sapiens ]
Official Symbol CAMLG
Synonyms CAMLG; calcium modulating ligand; calcium signal-modulating cyclophilin ligand; calcium modulating cyclophilin ligand; calcium signal modulating cyclophilin ligand; CAML; cyclophilin B binding protein; cyclophilin B-binding protein; calcium-modulating cyclophilin ligand; calcium-signal modulating cyclophilin ligand; MGC163197;
Gene ID 819
mRNA Refseq NM_001745
Protein Refseq NP_001736
MIM 601118
UniProt ID P49069
Chromosome Location 5q23
Function protein binding;

Not For Human Consumption!

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