Recombinant Human CAMLG, His-tagged
Cat.No. : | CAMLG-15870H |
Product Overview : | Recombinant human CAMLG protein, fused to His tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
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Species : | Human |
Source : | E.coli |
Tag : | His |
Protein Length : | 1-189aa |
Description : | The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. CAMLG functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol |
Molecular Mass : | 23.2 kDa (212aa), confirmed by MALDI-TOF |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSMESMAVA TDGGERPGVP AGSGLSASQR RAELRRRKLL MNSEQRINRI MGFHRPGSGA EEESQTKSKQ QDSDKLNSLS VPSVSKRVVL GDSVSTGTTD QQGGVAEVKG TQLGDKLDSF IKPPECSSDV NLELRQRNRG DLTADSVQRG SRHGLEQYLS RFEEAMKLRK QLISEKPSQE DGNTTEEFDS FR |
Purity : | >85% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at 4°C short term. For long term storage, aliquot and store at at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.5 mg/ml (determined by Bradford assay) |
Gene Name | CAMLG calcium modulating ligand [ Homo sapiens ] |
Official Symbol | CAMLG |
Synonyms | CAMLG; calcium modulating ligand; calcium signal-modulating cyclophilin ligand; calcium modulating cyclophilin ligand; calcium signal modulating cyclophilin ligand; CAML; cyclophilin B binding protein; cyclophilin B-binding protein; calcium-modulating cyclophilin ligand; calcium-signal modulating cyclophilin ligand; MGC163197; |
Gene ID | 819 |
mRNA Refseq | NM_001745 |
Protein Refseq | NP_001736 |
MIM | 601118 |
UniProt ID | P49069 |
Chromosome Location | 5q23 |
Function | protein binding; |
◆ Recombinant Proteins | ||
Camlg-584R | Recombinant Rat Camlg Protein, His/GST-tagged | +Inquiry |
CAMLG-1202M | Recombinant Mouse CAMLG Protein, His (Fc)-Avi-tagged | +Inquiry |
CAMLG-446R | Recombinant Rhesus Macaque CAMLG Protein, His (Fc)-Avi-tagged | +Inquiry |
Caml-583M | Recombinant Mouse Caml Protein, His-tagged | +Inquiry |
CAMLG-63H | Recombinant Human Calcium Modulating Ligand | +Inquiry |
◆ Cell & Tissue Lysates | ||
CAMLG-7872HCL | Recombinant Human CAMLG 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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