Recombinant Human CALM1, His-tagged

• Cat.No.: CALM1-89H
• Product Overview: The recombinant human Calmodulin 1 (full-length), fused with an N-terminal His tag, was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Calmodulin 1 is a member of calcium-modulated proteins, which is present in the cytosol and on membranes facing the cytosol, and has a high affinity for calcium. Calmodulin 1 has 4 calcium-binding domains and plays a role in cell growth, cell cycle, signal transduction, and the synthesis and release of neurotransmitters. Calmodulin can bind to the epidermal growth factor receptor at its cytosolic juxtamembrane region and this inhibits its tyrosine kinase activity. A number of other proteins including HSP70 have been shown to interact with Calmodulin 1 in a cell-phase-specific manner.
• Molecular weight: ~17 kDa
• Formulation: Recombinant protein stored in 50 mM sodiumphosphate, pH 7.0, 300 mMNaCl, 150 mM imidazole,0.1 mM PMSF, 0.25 mM DTT, and 25% glycerol.
• Stability: The product ships on dry ice and storage at –70 °C is recommended. After opening, aliquot into smaller quantities and store at –70 °C. Avoid repeated handling and multiple freeze/thaw cycles.
• Purity: 70–95% as determined by SDS-PAGE.

Gene Information

• Gene Name: CALM1 calmodulin 1 (phosphorylase kinase, delta) [ Homo sapiens ]
• Official Symbol: CALM1
• Synonyms: CALM1; calmodulin 1 (phosphorylase kinase, delta); CAMI; PHKD; DD132; CALML2; calmodulin 1; phosphorylase kinase, delta subunit; EC 2.7.11.19; CALMCAM; CAM1; CAM2; CAM3; CAMB; CAMC; CAMIII; CaM
• Gene ID: 801
• mRNA Refseq: NM_006888
• Protein Refseq: NP_008819
• MIM: 114180
• UniProt ID: P62158
• Chromosome Location: 14q24-q31
• Pathway: Alzheimer"s disease; Calcium signaling pathway; Glioma; GnRH signaling pathway; Insulin signaling pathway; Long-term potentiation; Melanogenesis; Neurotrophin signaling pathway; Olfactory transduction; Phosphatidylinositol signaling system; Vascular smooth muscle contraction