Recombinant Human CALD1
Cat.No. : | CALD1-26059TH |
Product Overview : | Recombinant full length protein, corresponding to amino acids 1-538 of Human Caldesmon, with an N-terminal proprietary tag, predicted MWt 85.25 kDa |
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Species : | Human |
Source : | Wheat Germ |
Tag : | Non |
Protein Length : | 538 amino acids |
Description : | This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. |
Molecular Weight : | 85.250kDa inclusive of tags |
Tissue specificity : | High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart. |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the caldesmon family. |
Gene Name | CALD1 caldesmon 1 [ Homo sapiens ] |
Official Symbol | CALD1 |
Synonyms | CALD1; caldesmon 1; caldesmon; CDM; H CAD; L CAD; |
Gene ID | 800 |
mRNA Refseq | NM_004342 |
Protein Refseq | NP_004333 |
MIM | 114213 |
Uniprot ID | Q05682 |
Chromosome Location | 7q33 |
Pathway | Muscle contraction, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; Smooth Muscle Contraction, organism-specific biosystem; Vascular smooth muscle contraction, organism-specific biosystem; Vascular smooth muscle contraction, conserved biosystem; |
Function | actin binding; calmodulin binding; myosin binding; tropomyosin binding; |
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Cald1-6815R | Recombinant Rat Cald1 protein, His & T7-tagged | +Inquiry |
CALD1-46HF | Recombinant Full Length Human CALD1 Protein | +Inquiry |
◆ Cell & Tissue Lysates | ||
CALD1-274HCL | Recombinant Human CALD1 cell lysate | +Inquiry |
Not For Human Consumption!
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