Recombinant Human CALD1

Cat.No. : CALD1-26059TH
Product Overview : Recombinant full length protein, corresponding to amino acids 1-538 of Human Caldesmon, with an N-terminal proprietary tag, predicted MWt 85.25 kDa
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Species : Human
Source : Wheat Germ
Tag : Non
Protein Length : 538 amino acids
Description : This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
Molecular Weight : 85.250kDa inclusive of tags
Tissue specificity : High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the caldesmon family.
Gene Name CALD1 caldesmon 1 [ Homo sapiens ]
Official Symbol CALD1
Synonyms CALD1; caldesmon 1; caldesmon; CDM; H CAD; L CAD;
Gene ID 800
mRNA Refseq NM_004342
Protein Refseq NP_004333
MIM 114213
Uniprot ID Q05682
Chromosome Location 7q33
Pathway Muscle contraction, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; Smooth Muscle Contraction, organism-specific biosystem; Vascular smooth muscle contraction, organism-specific biosystem; Vascular smooth muscle contraction, conserved biosystem;
Function actin binding; calmodulin binding; myosin binding; tropomyosin binding;

Not For Human Consumption!

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