Recombinant Human Calcyclin Binding Protein, His-tagged

• Cat.No.: CACYBP-54H
• Product Overview: Recombinant human CACYBP protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW =23.4 kDa (205aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: CACYBP is primarily a nuclear protein that contains one CS domain and one SGS domain. It is believed to be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It most likely serves as a molecular bridge in Ubiquitin E3 complexes. It also participates in the Ubiquitin-mediated degradation of β-catenin. CACYBP is thought to be a potential inhibitor of cell growth and invasion in the gastric cancer cell through its effects on β-catenin protein expression and transcriptional activation of TCF/LEF.
• Form: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol 1mM DTT, 0.1M NaCl.
• Purity: > 85% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MQQKSQKKAE LLDNEKPAAV VAPITTGYTV KISNYGWDQS DKFVKIYITL TGVHQVPTEN VQVHFTERSF DLLVKNLNGK SYSMIVNNLL KPISVEGSSK KVKTDTVLIL CRKKVENTRW DYLTQVEKEC KEKEKPSYDT ETDPSEGLMN VLKKIYEDGD DDMKRTINKA WVESREKQAK GDTEF.
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: CACYBP calcyclin binding protein [ Homo sapiens ]
• Synonyms: calcyclin binding protein; SIP; GIG5; MGC87971; PNAS-107; S100A6BP; RP1-102G20.6; CACYBP; calcyclin-binding protein; hCacyBP; S100A6-binding protein; Siah-interacting protein (SIP); growth-inhibiting gene 5 protein;OTTHUMP00000201857; Siah-interacting protein; CacyBP
• Gene ID: 27101
• mRNA Refseq: NM_001007214
• Protein Refseq: NP_001007215
• MIM: 606186
• UniProt ID: Q9HB71
• Chromosome Location: 1q24-q25
• Pathway: Wnt signaling pathway
• Function: protein binding; protein homodimerization activity