Recombinant Human C10orf54, His-tagged

• Cat.No.: C10orf54-837H
• Product Overview: Recombinant Human C10orf54(Met1-Ala194) fussed with His tag at C-terminal was expressed in Human Cells.

Specification

• Species: Human
• Source: Human Cells
• Tag: His
• Protein Length: 1-194 a.a.
• Description: C10orf54, also known as GI24, belongs to the immunoglobulin superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESCs, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, C10orf54 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.
• Predicted N Terminal: Phe 33
• Form: Lyophilized from sterile PBS, pH 7.4
• Molecular Mass: The recombinant human Gi24 consists of 173 amino acids and predicts a molecular mass of 19.6 KDa. It migrates as an approximately 38-42 KDa band in SDS-PAGE under reducing conditions.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Usage: FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE
• Stability: Samples are stable for up to twelve months from date of receipt at -70 centigrade
• Storage: Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: C10orf54 chromosome 10 open reading frame 54 [ Homo sapiens ]
• Official Symbol: C10orf54
• Synonyms: B7H5; GI24; B7-H5; SISP1; PP2135; platelet receptor Gi24; sisp-1; stress induced secreted protein 1; stress-induced secreted protein-1
• Gene ID: 64115
• mRNA Refseq: NM_022153
• Protein Refseq: NP_071436
• MIM: 615608
• UniProt ID: Q9H7M9
• Chromosome Location: 10q22.1