Recombinant Human BRD3, GST-tagged

• Cat.No.: BRD3-157H
• Product Overview: Recombinant Human BRD3 bromodomain 1 (24-144 aa) fused to a GST tag at the N-terminus

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 24-144 a.a.
• Description: The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT. The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions. The isolated individual or tandem bromodomains of BRD3 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters. Small molecule inhibitors of these interactions hold promise as useful therapeutics for human disease.
• Form: Liquid. 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.
• Molecular Mass: 41.2 kDa (24-144 aa + NT GST Tag)
• Purity: ≥95%
• Storage: Store at -80°C. Avoid repeated freeze and thaw cycles. Stable for 1 year.

Gene Information

• Gene Name: BRD3 bromodomain containing 3 [ Homo sapiens ]
• Official Symbol: BRD3
• Synonyms: BRD3; bromodomain containing 3; bromodomain-containing protein 3; KIAA0043; ORFX; RING3 like; RING3L; RING3-like protein; bromodomain-containing 3; FLJ23227; FLJ41328
• Gene ID: 8019
• mRNA Refseq: NM_007371
• Protein Refseq: NP_031397
• MIM: 601541
• UniProt ID: Q15059
• Chromosome Location: 9q34
• Function: molecular_function; protein binding