Recombinant Human BRD1, GST-tagged

• Cat.No.: BRD1-1900H
• Product Overview: Recombinant Human BRD1 (556-680 aa) was expressed in E. coli.

Specification

• Description: The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as "readers" of histone acetylation marks regulating the transcription of target promoters. BRD1 is a bromodomain containing protein that has been identified as a susceptibility gene in neurological disorders, such as schizophrenia and bipolar affective disorder. This protein can be used for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.
• Source: E. coli
• Species: Human
• Tag: GST
• Appearance: Liquid
• Form: 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.
• Molecular Mass: 41.1 kDa (556-680 aa + NT GST Tag)
• Protein length: 556-680 aa
• Purity: ≥95% by SDS-PAGE
• Usage: For Research Use Only! Not For Use in Humans.
• Storage: Store at -80°C. Avoid repeated freeze and thaw cycles. Stable for 1 year.

Gene Information

• Gene Name: BRD1 bromodomain containing 1 [ Homo sapiens (human) ]
• Official Symbol: BRD1
• Synonyms: BRD1; bromodomain containing 1; BRL; BRPF1; BRPF2; bromodomain-containing protein 1; BR140-like protein; bromodomain and PHD finger-containing protein 2
• Gene ID: 23774
• mRNA Refseq: NM_014577
• Protein Refseq: NP_055392
• MIM: 604589
• UniProt ID: O95696
• Chromosome Location: 22q13.33
• Function: histone binding; zinc ion binding