Recombinant Human BRAF Protein, Full Length, GST tagged

• Cat.No.: BRAF-12HFL
• Product Overview: Recombinant Human BRAF protein (Full Length) with GST tag was expressed in insect cells.

Specification

• Species: Human
• Source: Insect cells
• Tag: GST
• Protein Length: Full Length
• Description: This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome.
• Form: Liquid
• Molecular Mass: 113.6 kDa
• Applications: Kinase Assay (KA)
• Storage: At -80 centigrade, Avoid Freeze/Thaw Cycles
• Storage Buffer: 50mM tris, pH 7.5, with 50% glycerol, 0.02% Triton X-100, 150mM NaCl, 0.5mM EDTA, 2mM DTT
• Shipping: Dry ice

Gene Information

• Gene Name: BRAF B-Raf proto-oncogene, serine/threonine kinase [ Homo sapiens (human) ]
• Official Symbol: BRAF
• Synonyms: BRAF; B-Raf proto-oncogene, serine/threonine kinase; NS7; B-raf; BRAF1; RAFB1; B-RAF1; BRAF-1; serine/threonine-protein kinase B-raf; 94 kDa B-raf protein; B-Raf proto-oncogene serine/threonine-protein kinase (p94); B-Raf serine/threonine-protein; murine sarcoma viral (v-raf) oncogene homolog B1; proto-oncogene B-Raf; v-raf murine sarcoma viral oncogene homolog B; v-raf murine sarcoma viral oncogene homolog B1; EC 2.7.11.1
• Gene ID: 673
• mRNA Refseq: NM_004333
• Protein Refseq: NP_004324
• MIM: 164757
• UniProt ID: P15056