Recombinant Human BMF, His-tagged
| Cat.No. : | BMF-26283TH |
| Product Overview : | Recombinant full length Human Bmf isoform 3 , fused to 15 amino acid His Tag at the N-terminus, predicted MWt 15.6kDa including the tag. |
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| Description : | The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Protein length : | 129 amino acids |
| Conjugation : | HIS |
| Molecular Weight : | 15.600kDa inclusive of tags |
| Source : | E. coli |
| Tissue specificity : | Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells. |
| Form : | Liquid |
| Purity : | >90% by SDS-PAGE |
| Storage buffer : | pH: 7.50Constituents:0.32% Tris HCl, 0.02% DTT, 10% Glycerol |
| Storage : | Please see Notes section |
| Sequences of amino acids : | MASMTGGQQM GRGSHMEPSQ CVEELEDDVF QPEDGEPVTQ PGSLLSADLF AQSLLDCPLS RLQLFPLTHC CGPGLRPTSQ EDKATQTLSPASPSQGVMLP CGVTEEPQRL FYAPAEPKSC VVADPPLPAQ PCFEWRREQE RGRP |
| Sequence Similarities : | Belongs to the Bcl-2 family. |
| Gene Name | BMF Bcl2 modifying factor [ Homo sapiens ] |
| Official Symbol | BMF |
| Synonyms | BMF; Bcl2 modifying factor; bcl-2-modifying factor; FLJ00065; |
| Gene ID | 90427 |
| mRNA Refseq | NM_033503 |
| Protein Refseq | NP_277038 |
| MIM | 606266 |
| Uniprot ID | Q96LC9 |
| Chromosome Location | 15q14 |
| Pathway | Activation of BH3-only proteins, organism-specific biosystem; Activation of BMF and translocation to mitochondria, organism-specific biosystem; Apoptosis, organism-specific biosystem; Intrinsic Pathway for Apoptosis, organism-specific biosystem; |
| Function | protein binding; |
Not For Human Consumption!
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