Recombinant Human BCCIP, GST-tagged

• Cat.No.: BCCIP-10171H
• Product Overview: Recombinant Human BCCIP protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 1-314a.a.
• Description: This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: BCCIP BRCA2 and CDKN1A interacting protein [ Homo sapiens ]
• Official Symbol: BCCIP
• Synonyms: BCCIP; BRCA2 and CDKN1A interacting protein; BRCA2 and CDKN1A-interacting protein; BCCIPalpha; TOK 1; BCCIPbeta; TOK-1beta; TOK-1alpha; protein TOK-1; cdk inhibitor p21 binding protein; p21- and CDK-associated protein 1; BRCA2 and Cip1/p21 interacting protein; TOK1; TOK-1
• Gene ID: 56647
• mRNA Refseq: NM_016567
• Protein Refseq: NP_057651
• MIM: 611883
• UniProt ID: Q9P287
• Chromosome Location: 10q26.2
• Function: kinase regulator activity; protein binding