Recombinant Human BBC3 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: BBC3-562H
• Product Overview: BBC3 MS Standard C13 and N15-labeled recombinant protein (NP_001120712) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.
• Molecular Mass: 26.3 kDa
• AA Sequence: MKFGMGSAQACPCQVPRAASTTWVPCQICGPRERHGPRTPGGQLPGARRGPGPRRPAPLPARPPGALGSVLRPLRARPGCRPRRPHPAARCLPLRPHRPTRRHRRPGGFPLAWGSPQPAPRPAPGRSSALALAGGAAPGVARAQRPGGSGGRSHPGGPGSPRGGGTVGPGDRGPAAADGGRPQRTVRAAETRGAAAAPPLTLEGPVQSHHGTPALTQGPQSPRDGAQLGACTRPVDVRDSGGRPLPPPDTLASAGDFLCTMTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: BBC3 BCL2 binding component 3 [ Homo sapiens (human) ]
• Official Symbol: BBC3
• Synonyms: BBC3; BCL2 binding component 3; bcl-2-binding component 3; JFY1; PUMA; p53 up-regulated modulator of apoptosis; JFY-1; FLJ42994
• Gene ID: 27113
• mRNA Refseq: NM_001127240
• Protein Refseq: NP_001120712
• MIM: 605854
• UniProt ID: Q96PG8