Recombinant Human ATN1, His-tagged

• Cat.No.: ATN1-3772H
• Product Overview: Atrophin-1 (ATN1), partial

Specification

• Description: Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-23 copies to 49-75 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein.
• Source: E. Coli or Yeast
• Species: Human
• Tag: His
• Form: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Protein length: 1190
• Purity: >90%
• Notes: Small volumes of ATN1 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
• Storage Buffer: PBS pH 7.4, 50% glycerol
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: ATN1 atrophin 1 [ Homo sapiens ]
• Official Symbol: ATN1
• Synonyms: ATN1; atrophin 1; D12S755E, dentatorubral pallidoluysian atrophy (atrophin 1) , DRPLA; atrophin-1; B37; dentatorubral-pallidoluysian atrophy protein; HRS; NOD; DRPLA; D12S755E
• Gene ID: 1822
• mRNA Refseq: NM_001007026
• Protein Refseq: NP_001007027
• MIM: 607462
• UniProt ID: P54259
• Chromosome Location: 12p
• Function: JUN kinase binding; protein binding; protein domain specific binding; toxin receptor binding; transcription corepressor activity