Recombinant Human ATF3 protein, His-SUMO-tagged

• Cat.No.: ATF3-23H
• Product Overview: Recombinant Human ATF3, fused with His-SUMO tag, was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His&SUMO
• Protein Length: 342aa(including fusion tag)
• Description: This protein binds the cAMP response element (CRE) (consensus: 5"-GTGACGT[AC][AG]-3"), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.
• Form: 20mM Tris.Cl, 50mM NaCl, 20% Glycerol, pH8.0.
• Molecular Mass: 38.2kDa(including fusion tag)
• Applications: WB, ELISA, IP, antibody production, protein array
• Storage: Store at -80°C and avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: ATF3 activating transcription factor 3 [ Homo sapiens ]
• Official Symbol: ATF3
• Synonyms: ATF3; FLJ41705
• Gene ID: 467
• mRNA Refseq: NM_001030287
• Protein Refseq: NP_001025458
• MIM: 603148
• UniProt ID: P18847
• Chromosome Location: ATF-2 transcription factor network, organism-specific biosystem; Activation of Genes by ATF4, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; Disease, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem
• Pathway: identical protein binding; protein binding; protein dimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription corepressor activity