Recombinant Human APC Protein, His-tagged

• Cat.No.: APC-01H
• Product Overview: Purified recombinant protein of Human adenomatous polyposis coli (APC), transcript variant 1,Glu955-Leu1382, with N-terminal His tag, expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 955-1382 a.a.
• Description: This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
• Molecular Mass: 47.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 µg/mL as determined by microplate BCA method
• Storage Buffer: 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol.

Gene Information

• Gene Name: APC APC regulator of WNT signaling pathway [ Homo sapiens (human) ]
• Official Symbol: APC
• Synonyms: APC; APC regulator of WNT signaling pathway; GS; DP2; DP3; BTPS2; DESMD; DP2.5; PPP1R46; adenomatous polyposis coli protein; APC, WNT signaling pathway regulator; WNT signaling pathway regulator; adenomatosis polyposis coli tumor suppressor; adenomatous polyposis coli (APC); deleted in polyposis 2.5; epididymis secretory sperm binding protein; protein phosphatase 1, regulatory subunit 46; truncated adenomatosis polyposis coli
• Gene ID: 324
• mRNA Refseq: NM_001127511
• Protein Refseq: NP_001120983
• MIM: 611731
• UniProt ID: P25054