Recombinant Human ANTXR1 Protein, MYC/DDK-tagged

• Cat.No.: ANTXR1-2158H
• Product Overview: Recombinant human ANTXR1 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008].
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 34.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: ANTXR1 anthrax toxin receptor 1 [ Homo sapiens ]
• Official Symbol: ANTXR1
• Synonyms: ATR; GAPO; TEM8
• Gene ID: 84168
• mRNA Refseq: NM_018153
• Protein Refseq: NP_060623
• MIM: 606410
• UniProt ID: Q9H6X2