Recombinant Human ALS2 Protein, His-tagged

Cat.No. : ALS2-166H
Product Overview : Recombinant Human ALS2, transcript variant 2, fused with His tag at N-terminal was expressed in E. coli.
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Species : Human
Source : E.coli
Tag : His
Description : The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.
Form : 50mM Tris, 8M Urea, pH8.0.
Molecular Mass : 42.4 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name ALS2 amyotrophic lateral sclerosis 2 (juvenile) [ Homo sapiens ]
Official Symbol ALS2
Synonyms ALS2; amyotrophic lateral sclerosis 2 (juvenile); ALS2CR6, amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 6; alsin; amyotrophic lateral sclerosis 2 protein; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein; ALSJ; PLSJ; IAHSP; ALS2CR6; FLJ31851; KIAA1563; MGC87187;
Gene ID 57679
mRNA Refseq NM_001135745
Protein Refseq NP_001129217
MIM 606352
UniProt ID Q96Q42

Not For Human Consumption!

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