Recombinant Human AKR1C2, MYC/DDK-tagged

• Cat.No.: AKR1C2-18H
• Product Overview: Recombinant Human AKR1C2, fused with C-terminal MYC/DDK, was expressed in HEK293 cells

Specification

• Description: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene.
• Source: HEK293 cells
• Species: Human
• Tag: Myc&DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 Mm glycine, 10% glycerol.
• Molecular Mass: 36.6 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: AKR1C2 aldo-keto reductase family 1, member C2 [ Homo sapiens ]
• Official Symbol: AKR1C2
• Synonyms: DD; DD2; TDD; BABP; DDH2; HBAB; HAKRD; MCDR2; SRXY8; AKR1C-pseudo; aldo-keto reductase family 1 member C2; DD-2; DD/BABP; 3-alpha-HSD3; pseudo-chlordecone reductase; type II dihydrodiol dehydrogenase; chlordecone reductase homolog HAKRD; testicular 17,20-desmolase deficiency; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III
• Gene ID: 1646
• mRNA Refseq: NM_001354
• Protein Refseq: NP_001345
• MIM: 600450
• UniProt ID: P52895
• Chromosome Location: 10p15-p14
• Pathway: Benzo(a)pyrene metabolism, organism-specific biosystem; Chemical carcinogenesis, organism-specific biosystem; Metabolism of xenobiotics by cytochrome P450, conserved biosystem
• Function: alditol:NADP+ 1-oxidoreductase activity; bile acid binding; carboxylic acid binding