Recombinant Human ADAMTS1, GST-tagged

• Cat.No.: ADAMTS1-105H
• Product Overview: Recombinant Human ADAMTS1 was expressed as gst-tagged fusion protein by E.Coli and puri?ed by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 253-546aa
• Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.
• Storage: The protein is stored in PBS buffer at -20oC. Repeated freezethaw cycles should be avoided.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 [ Homo sapiens (human) ]
• Official Symbol: ADAMTS1
• Synonyms: ADAMTS1; C3-C5; METH1; ADAM metallopeptidase with thrombospondin type 1 motif, 1; A disintegrin and metalloproteinase with thrombospondin motifs 1; METH-1; ADAM-TS1; ADAMTS-1; ADAM-TS 1; human metalloproteinase with thrombospondin type 1 motifs; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1
• Gene ID: 9510
• mRNA Refseq: NM_006988
• Protein Refseq: NP_008919
• MIM: 605174
• UniProt ID: Q9UHI8
• Chromosome Location: 21q21.2
• Pathway: Endochondral Ossification
• Function: heparin binding; metalloendopeptidase activity; metallopeptidase activity