Recombinant Human ACTN2, His-tagged
Cat.No. : | ACTN2-31382TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 261-886 of Human Sarcomeric Alpha Actinin, with N terminal His tag, 626 amino acids, 72kDa, , |
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Species : | Human |
Source : | E.coli |
Tag : | His |
Protein Length : | 261-886 a.a. |
Description : | Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. |
Conjugation : | HIS |
Tissue specificity : | Expressed in both skeletal and cardiac muscle. |
Form : | Lyophilised:Reconstitution with 136 μl aqua dest. |
Storage buffer : | Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | QAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRT IPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEK CQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQ RLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETW AYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAH QDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDR LGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNN WMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADG ERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELR TKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQA NAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGW ELLLTTIARTINEVETQILTRDAKGITQEQMNEFRASF NHFDRRKNGLMDHEDFRACLISMGYDLGEAEFARIMTL VDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILAS DKPYILAEELRRELPPDQAQYCIKRMPAYSGPGSVPGA LDYAAFSS |
Sequence Similarities : | Belongs to the alpha-actinin family.Contains 1 actin-binding domain.Contains 2 CH (calponin-homology) domains.Contains 2 EF-hand domains.Contains 4 spectrin repeats. |
Gene Name | ACTN2 actinin, alpha 2 [ Homo sapiens ] |
Official Symbol | ACTN2 |
Synonyms | ACTN2; actinin, alpha 2; alpha-actinin-2; |
Gene ID | 88 |
mRNA Refseq | NM_001103 |
Protein Refseq | NP_001094 |
MIM | 102573 |
Uniprot ID | P35609 |
Chromosome Location | 1q42-q43 |
Pathway | Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; |
Function | FATZ 1 binding; ZASP binding; actin binding; calcium ion binding; identical protein binding; |
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Not For Human Consumption!
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