Active Recombinant Human ACE2 Protein, FLAG-tagged, Biotinylated
Online Order| Cat.No | Protein Length | MW | DataSheet |
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| Cat.No. | Purity | Endotoxin | Bio-activity | Applications |
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- Specification
- Gene Information
- Related Products
| Species : | Human |
| Source : | HEK293 |
| Tag : | Flag |
| Protein Length : | 18-740 |
| Description : | The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. |
| Bio-activity : | ACE2 Human, HEK293 Recombinant binds with high affinity to the Spike S1RBD protein of the virus SARS-CoV-2. ACE2 Human, HEK293 Recombinant was coated on an ELISA plate at 1μg/ml overnight at 4 centigrade. Recombinant SARS-CoV-2 Spike Protein S1RBD was added (starting at a concentration of 500 ng/mL with a two-fold serial dilution) during one hour at RT and the interaction was then detected using an anti-human IgG (HRP). |
| Molecular Mass : | ~110kDa (SDS-PAGE) ~240kDa (Dimer, by SEC) |
| Endotoxin : | <0.01 EU/μg (LAL test). |
| Purity : | ≥ 95% |
| Applications : | Cell culture and/or animal studies, In vitro, COVID-19 |
| Storage : | Stable for at least 6 months after receipt when stored at -20 centigrade. After opening, prepare aliquots and store at -20 centigrade. Working aliquots are stable for up to 3 months when stored at -20 centigrade. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. |
| Storage Buffer : | 1 mg/mL after reconstitution. Lyophilized. Contains PBS. |
| Reconstitution : | Reconstitute with 50 μL endotoxin-free water. |
| Shipping : | Shipped on ice packs. |
| Gene Name | ACE2 angiotensin converting enzyme 2 [ Homo sapiens (human) ] |
| Official Symbol | ACE2 |
| Synonyms | ACE2; angiotensin converting enzyme 2; ACEH; angiotensin-converting enzyme 2; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; angiotensin-converting enzyme homolog; angiotensin-converting enzyme-related carboxypeptidase; metalloprotease MPROT15; peptidyl-dipeptidase A; EC 3.4.17.23 |
| Gene ID | 59272 |
| mRNA Refseq | NM_021804 |
| Protein Refseq | NP_068576 |
| MIM | 300335 |
| UniProt ID | Q9BYF1 |
| ◆ Recombinant Proteins | ||
| ACE2-26H | Recombinant Human ACE2 Protein (ECD, processed, AA 20-708), Tag-free | +Inquiry |
| ACE2-25H | Recombinant Human ACE2 Protein (ECD, processed, AA 20-708), Tag-free | +Inquiry |
| ACE2-35M | Recombinant Mouse ACE2 Protein, His-tagged | +Inquiry |
| ACE2-39H | Recombinant Human ACE2 Protein, His-tagged | +Inquiry |
| ACE2-01H | Recombinant Human ACE2 protein, His-Avi-tagged | +Inquiry |
| ◆ Cell & Tissue Lysates | ||
| ACE2-887CCL | Recombinant Cynomolgus ACE2 cell lysate | +Inquiry |
| ACE2-1851RCL | Recombinant Rat ACE2 cell lysate | +Inquiry |
| ACE2-2085MCL | Recombinant Mouse ACE2 cell lysate | +Inquiry |
| ACE2-3100HCL | Recombinant Human ACE2 cell lysate | +Inquiry |
Not For Human Consumption!
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