Recombinant Human ABCC8 Protein, GST-Tagged

• Cat.No.: ABCC8-053H
• Product Overview: Human ABCC8 partial ORF ( NP_000343, 611 a.a. - 710 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 36.74 kDa
• AA Sequence: SEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTM
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 [ Homo sapiens ]
• Official Symbol: ABCC8
• Synonyms: ABCC8; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; HRINS, SUR; ATP-binding cassette sub-family C member 8; ABC36; HHF1; HI; MRP8; PHHI; sulfonylurea receptor (hyperinsulinemia); SUR1; TNDM2; sulfonylurea receptor 1; ATP-binding cassette transporter sub-family C member 8; SUR; HRINS; SUR1delta2
• Gene ID: 6833
• mRNA Refseq: NM_000352
• Protein Refseq: NP_000343
• MIM: 600509
• UniProt ID: Q09428