Recombinant Human ABCC5 Protein (M1-G1437), eGFP, Strep II, 10×His tagged

• Cat.No.: ABCC5-0106H
• Product Overview: Recombinant Human ABCC5(M1-G1437 end) (E1355Q)-3C-eGFP-Strep II-10His Protein was expressed in Mammalian cell.

Specification

• Description: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro). Acts also as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins. Confers resistance to the antiviral agent PMEA. Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated. Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway. May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells.
• Source: Mammalian cell
• Species: Human
• Tag: His&StrepII&EGFP
• Form: Liquid
• Protein length: M1-G1437
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 80%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: 50mM Tris-HCl (pH 8.0), 150mM KCl, 2mM DTT, 2mM MgCl2, 0.06% digitonin
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 [ Homo sapiens (human) ]
• Official Symbol: ABCC5
• Synonyms: ABCC5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; multidrug resistance-associated protein 5; EST277145; MOAT C; MRP5; SMRP; ATP-binding cassette sub-family C member 5; multi-specific organic anion transporter C; canalicular multispecific organic anion transporter C; ABC33; MOATC; MOAT-C; pABC11; DKFZp686C1782
• Gene ID: 10057
• mRNA Refseq: NM_001023587
• Protein Refseq: NP_001018881
• MIM: 605251
• UniProt ID: O15440