Recombinant Hepatitis B Virus S protein, His-tagged

• Cat.No.: S-79H
• Product Overview: Recombinant Hepatitis B Virus Pre-S produced in E.coli is a full length Pre-S of HBV subtype adw2, containing 174 amino acids, having a molecular weight of about 25kDa including a vector sequence and linked with a 6xHis tag at C- terminus.

Specification

• Species: HBV
• Source: E.coli
• Tag: His
• Protein Length: 174 amino acids
• Description: Hepatitis B virus surface gene encodes 3 proteins: small (HBs), middle (MHBs) and large (LHBs) surface protein. These 3 proteins are translated from distinct start codons, however share a common reading frame and stop codon. HBs contains 226 amino acids, it is a major viral envelope component. MHBs has extra 55 amino acids (Pre-S2) located to the N-terminus of HBs, LHBs has an additional 119 amino acids (Pre-S1). Pre-S is a region is comprised of Pre-S1 and S2, Pre-S1 has a vital role in receptor recognition, while Pre-S2 plays a part in translocation of virus into host cell. Clinically, HBV pre-S is linked with HBsAg and HBV DNA copies, which indicates active replication of virus, reduction of pre-S is typically associated with decreased HBV DNA copies, pointing to an improved predictor of treatment. In addition, Pre-S is a potential vaccine under development to enhance currently used HBsAg vaccine.
• Form: Sterile Filtered solution. Sterile Filtered solution containing PBS, 1M urea and 0.05% sodium azide.
• Molecular Mass: 25kDa
• Purity: Protein is >95% pure as determined by 12% PAGE (coomassie staining).
• Applications: Immunoassay.
• Usage: The products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
• Storage: HBV Pre-S although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.
• Shipping: Ice Packs

Gene Information

• Gene Name: S long surface protein; PreS1; L protein; LHBs; large S protein; pre-S1/pre-S2/S regions; L glycoprotein; L-HBsAG; LHBs [ Hepatitis B virus ]
• Official Symbol: S
• Synonyms: S; long surface protein; PreS1; L protein; LHBs; large S protein; pre-S1/pre-S2/S regions; L glycoprotein; L-HBsAG; LHBs; large envelope protein; middle envelope protein; small envelope protein
• Gene ID: 944569
• Protein Refseq: YP_009173869.1
• UniProt ID: Q2F515