Recombinant Full Length mouse Mmp2 protein, His-tagged

• Cat.No.: Mmp2-23MFL
• Product Overview: Recombinant Full Length mouse Mmp2 protein, His-tagged,expressed in Baculovirus.

Specification

• Species: Mouse
• Source: Baculovirus
• Tag: His
• ProteinLength: 30-662aa
• Description: MMP-2, also known as Matrix metalloproteinase-2, is one of the f the matrix metalloproteinase (MMP) family.It is involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonicdevelopment, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis andmetastasis. It has a role in myocardial cell death pathways and contributes to myocardial oxidative stress byregulating the activity of GSK3beta. This protein cleaves GSK3beta in vitro and involved in the formation of the fibrovascular tissues. Recombinant mouse MMP-2, fused to His-tag , was expressed ininsect cell and purified by using conventional chromatography techniques.
• Tag: His
• Molecular Mass: 72.4 kDa
• AA Sequence: APSPI IKFPGDVAPK TDKELAVQYL NTFYGCPKES CNLFVLKDTL KKMQKFFGLP QTGDLDQNTI ETMRKPRCGN
  PDVANYNFFP RKPKWDKNQI TYRIIGYTPD LDPETVDDAF ARALKVWSDV TPLRFSRIHD GEADIMINFG RWEHGDGYPF
  DGKDGLLAHA FAPGTGVGGD SHFDDDELWT LGEGQVVRVK YGNADGEYCK FPFLFNGREY SSCTDTGRSD
  GFLWCSTTYN FEKDGKYGFC PHEALFTMGG NADGQPCKFP FRFQGTSYNS CTTEGRTDGY RWCGTTEDYD RDKKYGFCPE
  TAMSTVGGNS EGAPCVFPFT FLGNKYESCT SAGRNDGKVW CATTTNYDDD RKWGFCPDQG YSLFLVAAHE
  FGHAMGLEHS QDPGALMAPI YTYTKNFRLS HDDIKGIQEL YGPSPDADTD TGTGPTPTLG PVTPEICKQD IVFDGIAQIR
  GEIFFFKDRF IWRTVTPRDK PTGPLLVATF WPELPEKIDA VYEAPQEEKA VFFAGNEYWV YSASTLERGY PKPLTSLGLP
  PDVQQVDAAF NWSKNKKTYI FAGDKFWRYN EVKKKMDPGF PKLIADSWNA IPDNLDAVVD LQGGGHSYFF KGAYYLKLEN
  QSLKSVKFGS IKSDWLGC
• Purity: > 85% by SDS-PAGE
• Applications: SDS-PAGE
• Notes: For research use only. This product is not intended or approved for human, diagnostics or veterinary use.
• Storage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25mg/ml (determined by absorbance at 280nm)
• Storage Buffer: Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
• GeneID: 17390
• References: Shon SM., et al. (2017) Circ J. 81:1528-1536.
  Wu W., et al. (2018) Cell Cycle. 18:46-59.

Gene Information

• Gene Name: Mmp2 matrix metallopeptidase 2 [ Mus musculus (house mouse) ]
• Official Symbol: Mmp2
• Synonyms: Mmp2,72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, MMP-2, PEX, Clg4a, GelA,MMP-II, Matrix metalloproteinase-2
• mRNA Refseq: NM_008610
• Protein Refseq: NP_032636.1
• UniProt ID: P33434