Recombinant Full Length Human Prominin 1 / PROM1 Protein, Isoform 2, Untagged

• Cat.No.: PROM1-70H
• Product Overview: Recombinant Human PROM1 was expressed in wheat germ with proprietary liposome technology.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: Non
• Protein Length: 1-856 a.a.
• Description: This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene.
• Molecular Mass: 96.3 kDa
• Sequence: MALVLGSLLLLGLCGNSFSGGQPSSTDAPKAWNYELPATNYETQDSHKAGPIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKIVYYEAGIILCCVLGLLFIILMPLVGYFFCMCRCCNKCGGEMHQRQKENGPFLRKCFAISLLVICIIISIGIFYGFVANHQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQYNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDEIKSMATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLVHPSSETCNSIRLSLSQLNSNPELRQLPPVDAELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPIQDILSAFSVYVNNTESYIHRNLPTLEEYDSYWWLGGLVICSLLTLIVIFYYLGLLCGVCGYDRHATPTTRGCVSNTGGVFLMVGVGLSFLFCWILMIIVVLTFVFGANVEKLICEPYTSKELFRVLDTPYLLNEDWEYYLSGKLFNKSKMKLTFEQVYSDCKKNRGTYGTLHLQNSFNISEHLNINEHTGSISSELESLKVNLNIFLLGAAGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKANSLPPGNLRNSLKRDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTSSVIIEETKKYGRTIIGYFEHYLQWIEFSISEKVASCKPVATALDTAVDVFLCSYIIDPLNLFWFGIGKATVFLLPALIFAVKLAKYYRRMDSEDVYDDVETIPMKNMENGNNGYHKDHVYGIHNPVMTSPSQH
• Form: Liquid
• Storage buffer: 25 mM Tris-HCl of pH8.0 containing 2% glycerol.
• Applications: Antibody Production; Functional Study; Compound Screening
• Storage: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
• OfficialSymbol: PROM1

Gene Information

• Gene Name: PROM1 prominin 1 [Homo sapiens]
• Synonyms: prominin 1; prominin (mouse)-like 1; AC133; Stargardt disease 4 (autosomal dominant); CD133; OTTHUMP00000217744; RP41; OTTHUMP00000217745; PROML1; OTTHUMP00000217746; Antigen AC133; hProminin; Prominin-like protein 1; hematopoietic stem cell antigen; CORD12; prominin-1; MCDR2; prominin-like 1; STGD4; CD133 antigen; macular dystrophy, retinal 2; MSTP061
• Gene ID: 8842
• mRNA Refseq: NM_006017
• Protein Refseq: NP_006008
• MIM: 604365
• UniProt ID: O43490
• Chromosome Location: 4p15.32
• Function: actinin binding; cadherin binding; protein binding