Recombinant Full Length Human O-sialoglycoprotein endopeptidase Protein, His tagged

• Cat.No.: OSGEP-23HFL
• Product Overview: Recombinant human OSGEP protein (Full Length), fused to His-tag at N-terminus, was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-335aa
• Description: Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity and metal ion binding activity. Involved in tRNA threonylcarbamoyladenosine modification. Located in cytoplasm; nuclear speck; and plasma membrane. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 3.
• Tag: N-His
• Form: Liquid
• Molecular Mass: 38.8 kDa
• AA Sequence: MGSSHHHHHHSSGLVPRGSHMGSMPAVLGFEGSANKIGVGVVRDGKVLANPRRTYVTPPGTGFLPGDTARHHRAVILDLLQEALTESGLTSQDIDCIAYTKGPGMGAPLVSVAVVARTVAQLWNKPLVGVNHCIGHIEMGRLITGATSPTVLYVSGGNTQVIAYSEHRYRIFGETIDIAVGNCLDRFARVLKISNDPSPGYNIEQMAKRGKKLVELPYTVKGMDVSFSGILSFIEDVAHRMLATGECTPEDLCFSLQETVFAMLVEITERAMAHCGSQEALIVGGVGCNVRLQEMMATMCQERGARLFATDERFCIDNGAMIAQAGWEMFRAGHRTPLSDSGVTQRYRTDEVEVTWRD
• Purity: > 80% by SDS-PAGE
• Applications: SDS-PAGE, Denatured
• Storage: Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/mL (determined by Bradford assay)
• Storage Buffer: 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea
• Notes: For research use only. This product is not intended or approved for human, diagnostics or veterinary use.
• References: 1. Seki Y., et al (2002). Gene 285:101-108
  2. Burkard T.R., et al (2011). BMC Syst. Biol. 5:17-17

Gene Information

• Gene Name: OSGEP O-sialoglycoprotein endopeptidase [ Homo sapiens (human) ]
• Official Symbol: OSGEP
• Synonyms: OSGEP; O-sialoglycoprotein endopeptidase; KAE1; TCS3; GCPL1; GAMOS3; OSGEP1; PRSMG1; tRNA N6-adenosine threonylcarbamoyltransferase; N6-L-threonylcarbamoyladenine synthase; hOSGEP; probable O-sialoglycoprotein endopeptidase; probable tRNA N6-adenosine threonylcarbamoyltransferase; probable tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP; tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP; EC 2.3.1.234
• Gene ID: 55644
• mRNA Refseq: NM_017807
• Protein Refseq: NP_060277
• MIM: 610107
• UniProt ID: Q9NPF4