Recombinant Full Length Human GJA8 Protein, GST-tagged

• Cat.No.: GJA8-5292HF
• Product Overview: Human GJA8 full-length ORF ( AAI46508.1, 1 a.a. - 433 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome. [provided by RefSeq, Dec 2009]
• Molecular Mass: 74.58 kDa
• Protein length: 433 amino acids
• AA Sequence: MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPGCENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGTNGGPDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKRPVEQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFNQFEEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEEGAEPEVGEKKEEAERLTTEEQEKVAVPEGEKVETPGVDKEGEKEEPQSEKVSKQGLPAEKTPSLCPELTTDDARPLSRLSKASSRARSDDLTV
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: GJA8 gap junction protein, alpha 8, 50kDa [ Homo sapiens ]
• Official Symbol: GJA8
• Synonyms: GJA8; gap junction protein, alpha 8, 50kDa; CAE, CAE1, CZP1, gap junction protein, alpha 8, 50kD (connexin 50), gap junction protein, alpha 8, 50kDa (connexin 50); gap junction alpha-8 protein; connexin 50; CX50; connexin-50; lens fiber protein MP70; cell surface glycoprotein; lens intrinsic membrane protein MP70; gap junction membrane channel protein alpha-8; CAE; CAE1; CZP1; MP70
• Gene ID: 2703
• mRNA Refseq: NM_005267
• Protein Refseq: NP_005258
• MIM: 600897
• UniProt ID: P48165