Recombinant Full Length Human FRZB protein, His tagged

• Cat.No.: FRZB-001H
• Product Overview: Recombinant Full Length Human frizzled related protein (33-325 aa) with His tag was expressed in HEK293.

Specification

• Description: The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility.
• Source: HEK293
• Species: Human
• Tag: C-His
• Protein length: 33-325 aa
• Molecular Mass: 34 kDa
• AA Sequence: AACEPVRIPLCKSLPWNMTKMPNHL HHSTQANAILAIEQFEGLLGTHCSP DLLFFLCAMYAPICTIDFQHEPIKP CKSVCERARQGCEPILIKYRHSWPE NLACEELPVYDRGVCISPEAIVTAD GADFPMDSSNGNCRGASSERCKCKP IRATQKTYFRNNYNYVIRAKVKEIK TKCHDVTAVVEVKEILKSSLVNIPR DTVNLYTSSGCLCPPLNVNEEYIIM GYEDEERSRLLLVEGSIAEKWKDRL GKKVKRWDMKLRHLGLSKSDSSNSD STQSQKSGRNSNPRQARNHHHHHHH H
• Endotoxin: < 1 EU/μg by LAL.
• Purity: > 90 % by SDS-PAGE
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Sterile PBS, pH7.4
• Concentration: 1 mg/mL by BCA

Gene Information

• Gene Name: FRZB frizzled related protein [ Homo sapiens (human) ]
• Official Symbol: FRZB
• Synonyms: FRZB; frizzled-related protein; secreted frizzled-related protein 3; FRE; FRITZ; FRP 3; FRZB 1; FRZB PEN; FRZB1; FZRB; hFIZ; SFRP3; SRFP3; sFRP-3; frezzled; frizzled homolog-related; frizzled-related protein 1; OS1; FRP-3; FRZB-1; FRZB-PEN
• Gene ID: 2487
• mRNA Refseq: NM_001463
• Protein Refseq: NP_001454
• MIM: 605083
• UniProt ID: Q92765

Reviews

05/17/2020

The manufacturer's responsiveness to customer feedback demonstrated a commitment to continuous improvement.

01/09/2020

The availability of educational materials and training resources facilitated the onboarding of new team members.

02/06/2018

The seamless integration of the product with our lab equipment enhanced overall workflow efficiency.

Q&As

Are there therapeutic implications or potential targets related to FRZB in diseases involving Wnt signaling?

There are potential therapeutic implications related to FRZB in diseases involving Wnt signaling, making it a target for drug development.

How does FRZB contribute to the regulation of cell proliferation, differentiation, or tissue development?

FRZB contributes to the regulation of cell proliferation, differentiation, and tissue development by modulating Wnt signaling.

What is the primary function of frizzled-related protein (FRZB) in cellular processes and signaling?

Frizzled-related protein (FRZB) plays a role in cellular processes and signaling, acting as a modulator of Wnt pathways.

How does FRZB interact with Wnt signaling pathways, and what is its role in modulating Wnt signaling?

FRZB interacts with Wnt signaling pathways by binding to Wnt ligands and acting as a soluble antagonist to inhibit Wnt activation.

What diseases or conditions are associated with dysregulation or abnormal expression of FRZB?

Dysregulation or abnormal expression of FRZB is associated with conditions such as osteoarthritis and certain cancers.

In which tissues or cell types is FRZB predominantly expressed?

FRZB is predominantly expressed in various tissues, including cartilage, bone, and certain developmental tissues.

Are there specific Wnt ligands or receptors that FRZB interacts with, influencing Wnt pathway activation?

Specific Wnt ligands or receptors that FRZB interacts with include Wnt-1 and Wnt-3a, influencing Wnt pathway activation.