Recombinant Full Length Human FAR1 Protein, GST-tagged

• Cat.No.: FAR1-4705HF
• Product Overview: Human FAR1 full-length ORF (BAG37908.1, 1 a.a. - 515 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 85.8 kDa
• Protein length: 515 amino acids
• AA Sequence: MVSIPEYYEGKNVLLTGATGFLGKVLLEKLLRSCPKVNSVYVLVRQKAGQTPQERVEEVLSGKLFDRLRDENPDFREKIIAINSELTQPKLALSEEDKEVIIDSTNIIFHCAATVRFNENLRDAVQLNVIATRQLILLAQQMKNLEVFMHVSTAYAYCNRKHIDEVVYPPPVDPKKLIDSLEWMDDGLVNDITPKLIGDRPNTYIYTKALAEYVVQQEGAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKGILRTIRASNNALADLVPVDVVVNMSLAAAWYSGVNRPRNIMVYNCTTGSTNPFHWGEVEYHVISTFKRNPLEQAFRRPNVNLTSNHLLYHYWIAVSHKAPAFLYDIYLRMTGRSPRMMKTITRLHKAMVFLEYFTSNSWVWNTENVNMLMNQLNPEDKKTFNIDVRQLHWAEYIENYCLGTKKYVLNEEMSGLPAARKHLNKLRNIRYGFNTILVILIWRIFIPRSQMARNIWYFVVSLCYKFLSYFRASSTMRY
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: FAR1 fatty acyl CoA reductase 1 [ Homo sapiens ]
• Official Symbol: FAR1
• Synonyms: FAR1; fatty acyl CoA reductase 1; male sterility domain containing 2 , MLSTD2; fatty acyl-CoA reductase 1; FLJ22728; SDR10E1; short chain dehydrogenase/reductase family 10E; member 1; putative fatty acyl reductase; male sterility domain containing 2; male sterility domain-containing protein 2; short chain dehydrogenase/reductase family 10E, member 1; MLSTD2; FLJ33561; DKFZp686A0370; DKFZp686P18247
• Gene ID: 84188
• mRNA Refseq: NM_032228
• Protein Refseq: NP_115604
• MIM: 616107
• UniProt ID: Q8WVX9