Recombinant Full Length Human DDR1 Protein, C-DDK-tagged

• Cat.No.: DDR1-826HFL
• Product Overview: Recombinant Full Length Human DDR1 Protein, fused to DDK-tag at C-terminus, was expressed in Sf9.

Specification

• Description: Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol.
• Molecular Mass: 97 kDa
• AA Sequence: A DNA sequence from TrueORF clone, RC201224, encoding human full-length DDR1.
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Full Length: Full L.

Gene Information

• Gene Name: DDR1 discoidin domain receptor tyrosine kinase 1 [ Homo sapiens (human) ]
• Official Symbol: DDR1
• Synonyms: CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A
• Gene ID: 780
• mRNA Refseq: NM_001954.5
• Protein Refseq: NP_001945.3
• MIM: 600408
• UniProt ID: Q08345