Recombinant Full Length Human DCLRE1C Protein, GST-tagged

• Cat.No.: DCLRE1C-2881HF
• Product Overview: Human DCLRE1C full-length ORF ( AAH22254, 1 a.a. - 434 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Species: Human
• Source: In Vitro Cell Free System
• Tag: GST
• Protein Length: 434 amino acids
• Description: This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
• Molecular Mass: 73.48 kDa
• AA Sequence: MSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLECSLKVYLYCSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEASGEKEEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAQGEAARMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSREECLSGVLELVRSWITRSPYHVVWLNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPEILRHLTTDRNTQIHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRKTNVIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVEILKPLCRSSQSTEPKYKPLGKLKRARTVHRDSGSHSVTQARMRWCHHDSLYPLTPGIKRSSCLSLLTSWITGAYRHAQLMI
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DCLRE1C DNA cross-link repair 1C [ Homo sapiens ]
• Official Symbol: DCLRE1C
• Synonyms: DCLRE1C; DNA cross-link repair 1C; DNA cross link repair 1C (PSO2 homolog, S. cerevisiae) , SCIDA, severe combined immunodeficiency, type a (Athabascan); protein artemis; A SCID; ARTEMIS; FLJ11360; PSO2 homolog (S. cerevisiae); SNM1C; PSO2 homolog; SNM1 homolog C; SNM1-like protein; DNA cross-link repair 1C protein; severe combined immunodeficiency, type a (Athabascan); DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae); SCIDA; A-SCID; hSNM1C; RS-SCID; DCLREC1C; FLJ36438
• Gene ID: 64421
• mRNA Refseq: NM_001033855
• Protein Refseq: NP_001029027
• MIM: 605988
• UniProt ID: Q96SD1