Recombinant Full Length Human CYP1A1 Protein

• Cat.No.: CYP1A1-114HF
• Product Overview: Recombinant full length Human Cytochrome P450 1A1 with N terminal proprietary tag; Predicted MWt 82.06 kDa.

Specification

• Species: Human
• Source: In Vitro Cell Free System
• Protein Length: 512 amino acids
• Description: This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzymes endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
• Form: Liquid
• Molecular Mass: 82.060kDa inclusive of tags
• AA Sequence: MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNP PGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGS TPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLE EHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICA ICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRD ITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFD TVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFY IPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAID KVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
• Purity: Proprietary Purification
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles.
• Storage Buffer: pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione.

Gene Information

• Gene Name: CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 [ Homo sapiens ]
• Official Symbol: CYP1A1
• Synonyms: CYP1A1; cytochrome P450, family 1, subfamily A, polypeptide 1; CYP1, cytochrome P450, subfamily I (aromatic compound inducible), polypeptide 1; cytochrome P450 1A1; CP11; P1 450; P450 C; P450DX
• Gene ID: 1543
• mRNA Refseq: NM_000499
• Protein Refseq: NP_000490
• MIM: 108330
• UniProt ID: P04798