Recombinant Full Length Human APLP2 Protein, GST-tagged

• Cat.No.: APLP2-1110HF
• Product Overview: Human APLP2 full-length ORF ( AAH04371.1, 1 a.a. - 522 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 85.6 kDa
• Protein length: 522 amino acids
• AA Sequence: MAATGTAAAA ATGRLLLLLL VGLTAPALAL AGYIEALAAN AGTGFAVAEP QIAMFCGKLN MHVNIQTGKW EPDPTGTKSC FETKEEVLQY CQEMYPELQI TNVMEANQRV SIDNWCRRDK KQCKSRFVTP FKCLVPPTPL PTNDVDVYFE TSADDNEHAR FQKAKEQLEI RHRNRMDRVK KEWEEAELQA KNLPKAERQT LIQHFQAMVK ALEKEAASEK QQLVETHLAR VEAMLNDRRR MALENYLAAL QSDPPRPHRI LQALRRYVRA ENKDRLHTIR HYQHVLAVDP EKAAQMKSQV MTHLHVIEER RNQTLSLLYK VPYVAQEIQE EIDELLQEQR ADMDQFTASI SETPVDVRVS SEESEEIPPF HPFHPFPALP ENEGSGVGEQ DGGLIGAEEK VINSKNKVDE NMVIDETLDV KEMIFNAERV GGLEEERESV GPLREDFSLS SSALIGLLVI AVAIATVIVI SLVMLRKRQY GTISHGIVEV DPMLTPEERH LNKMQNHGYE NPTYKYLEQM QI
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: APLP2 amyloid beta (A4) precursor-like protein 2 [ Homo sapiens ]
• Official Symbol: APLP2
• Synonyms: APLP2; amyloid beta (A4) precursor-like protein 2; APPL2; amyloid-like protein 2; APPH; CDEI box-binding protein; amyloid precursor protein homolog HSD-2; CDEBP; APLP-2
• Gene ID: 334
• mRNA Refseq: NM_001142276
• Protein Refseq: NP_001135748
• MIM: 104776
• UniProt ID: Q06481