Recombinant Dengue fever 1 NS1 antigen

• Cat.No.: POLY-0038D
• Product Overview: Recombinant Dengue fever 1 NS1 antigen without tag was expressed in HEK293.

Specification

• Species: DENV1
• Source: HEK293
• Description: Involved in immune evasion, pathogenesis and viral replication. Once cleaved off the polyprotein, is targeted to three destinations: the viral replication cycle, the plasma membrane and the extracellular compartment. Essential for viral replication. Required for formation of the replication complex and recruitment of other non-structural proteins to the ER-derived membrane structures. Excreted as a hexameric lipoparticle that plays a role against host immune response. Antagonizing the complement function. Binds to the host macrophages and dendritic cells. Inhibits signal transduction originating from Toll-like receptor 3 (TLR3).
• Applications: ELISA, CLIA, CG
• Notes: For research use only, not for use in diagnostic procedure.
• Storage: Short term (up to 7 days) store at 2–8 centigrade. Long term, store at - 20 centigrade. Avoid multiple freeze/thaw cycles.
• Storage Buffer: Supplied as a 0.2 μm filtered solution of PBS, pH7.4

Gene Information

• Gene Name: POLY polyprotein [ Dengue virus 1 ]
• Official Symbol: POLY
• Synonyms: POLY; polyprotein; polyprotein; anchored capsid protein ancC; membrane glycoprotein precursor prM; membrane glycoprotein M; envelope protein E; nonstructural protein NS1; nonstructural protein NS2A; nonstructural protein NS2B; nonstructural protein NS3; nonstructural protein NS4A; nonstructural protein NS4B; RNA-dependent RNA polymerase NS5; capsid protein C; protein 2K; protein pr
• Gene ID: 5075725
• Protein Refseq: NP_059433
• UniProt ID: P17763