Recombinant Cynomolgus CD4, His tagged

• Cat.No.: CD4-01H
• Product Overview: Recombinant Cynomolgus CD4 with C-terminal His6 fusion tag was expressed in HEK293.

Specification

• Species: Macaca Fascicularis
• Source: HEK293
• Tag: His
• Protein Length: 373
• Description: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages
• Form: Lyophilized powder
• Molecular Mass: 41.5 kDa
• AA Sequence: KKVVLGKKGDTVELTCNASQKKNTQFHWKNSNQIKILGIQGSFLTKGPSKLSDRADSRKSLWDQGCFSMIIKNLKIEDSDTYICEVENKKEEVELLVFGLTANSDTHLLEGQSLTLTLESPPGSSPSVKCRSPGGKNIQGGRTLSVPQLERQDSGTWTCTVSQDQKTVEFKIDIVVLAFQKASSTVYKKEGEQVEFSFPPAFTLEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQFQENLTCEVWGPTSPKLTLSLKLENKGTTVSKQAKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVVPTWHHHHHHHH
• Endotoxin: ＜1EU/ug by LAL
• Purity: ＞95% by SDS-PAGE
• Applications: ELISA
• Storage: Store it under sterile conditions at -20 to -80 ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Lyophilized from sterile PBS, pH 7.4. 5% trehalose and mannitol are added as protectants before lyophilization.

Gene Information

• Gene Name: CD4
• Official Symbol: CD4
• Synonyms: CD4mut,LEU3
• Gene ID: 101864991
• mRNA Refseq: MF632290.1
• Protein Refseq: P79185.1
• UniProt ID: P79185