Rat Anti-Havcr1 Monoclonal Antibody

• Cat.No.: DMAB36383
• Product Overview: Rat Anti-Havcr1 Monoclonal Antibody

Specification

• Species: Mouse
• Source: Rat
• Tag: Non
• Antigen Description: Tim-1 is highly expressed by activated CD4+ T cells, and acts as a positive/negative co-stimulatory molecule of T cell proliferation, cytokine production and tolerance abrogation, and is the receptor for Tim-4, expressed on APCs. Tim-1 expression is greater on Th2 than Th1 cells, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on dendritic cells (DCs), enhances Th2 cell function, and have implicated Tim-1 as a critical player in the development of atopic disease, and in particular airway hypersensitivity.
• specificity: It specifically recognises mouse Tim-1 (T-cell immunoglobulin mucin 1), a cell surface glycoprotein and member of the immunoglobulin superfamily, which was first identified as the hepatitis A virus cellular receptor (HAVCR), and is highly expressed in the liver (isoform Tim-1a) and the kidneys (isoform Tim-1b).
• Target: Havcr1
• Immunogen: Full-length mouse Tim-1-Ig, containing both the IgV and mucin domains of Tim-1.
• Isotype: IgG2a
• species: Mouse
• Clone: RMT1-10
• Purification: Purified IgG
• Conjugation: N/A
• Applications: ELISA,Flow Cyt,FunS,IFA
• Dilution: Flow Cytometry:1/25 - 1/200
• Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
• Protein Concentration: 1.0 mg/ml
• Storage: Store at -20°C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
• Shelf life: 18 months from date of despatch.
• Size: 0.5 mg

Gene Information

• Gene Name: Havcr1 hepatitis A virus cellular receptor 1 [ Mus musculus ]
• Official Symbol: Havcr1
• Synonyms: HAVCR1; hepatitis A virus cellular receptor 1; hepatitis A virus cellular receptor 1 homolog; TIMD-1; HAVcr-1; kidney injury molecule 1; t cell membrane protein 1; T-cell immunoglobulin and mucin domain containing 1; t cell immunoglobulin and mucin domain-containing protein 1; Tim1; KIM-1; TIM-1; Timd1; AI503787
• Gene ID: 171283
• mRNA Refseq: NM_001166631
• Protein Refseq: NP_001160103
• Function: receptor activity