Rabbit Anti-Mouse Interleukin-11 Receptor Alpha Chain Monoclonal Antibody

• Cat.No.: CAB11560RM
• Product Overview: Rabbit Monoclonal Antibody to Mouse Interleukin-11 Receptor Alpha Chain

Specification

• Antigen Description: Mouse interleukin-11 receptor alpha chain, also known as IL-11R-alpha, and IL11RA, is a single-pass type Imembrane protein. It belongs to the type Icytokine receptor family and type 3 subfamily and contains two fibronectin type-III domains and one Ig-like C2-type (immunoglobulin-like) domain. Interleukin 11 receptor is a heterodimer composed of an interleukin 11 receptor alpha subunit and an incompletely characterized beta subunit. IL11RA is expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. It is also expressed in normal and malignant prostate epithelial cell lines. IL11RA is a receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and differentiation of skeletogenic progenitor or other mesenchymal cells.
• Specificity: Mouse IL11RA / IL11Rα. No cross-reactivity with human cell lysate ( 293 cell line ) in WB and ELISA.
• Immunogen: Recombinant mouse IL11RA protein
• Host: Rabbit
• Isotype: Rabbit IgG
• Species: Mouse
• Cross Reactivity: 025
• Clone: A026
• Applications: WB; ELISA
• Dilution: Western blot: This antibody can be used at 1 - 2 μg/mL with the appropriate secondary reagents to detect mouse IL11RA in WB. Using a DAB detection system, the detection limit for mouse IL11RA is approximately 0.25 ng/lane under non-reducing conditions and reducing conditionsDirect ELISA: This antibody can be used at 0.1 - 0.2 μg/mL with the appropriate secondary reagents to detect mouse IL11RA. The detection limit for mouse IL11RA is approximately 0.00245 ng/well
• Preparation: This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant mouse IL11RA ( rM IL11RA ; NP_001156873.1 ; Met 1 - Gln 367 )
• Format: 0.2 μm filtered solution in PBS with 5% trehalose
• Storage: This antibody can be stored at 2-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
• Tag: Non

Gene Information

• Gene Name: Il11ra1 interleukin 11 receptor, alpha chain 1 [ Mus musculus ]
• Official Symbol: Il11ra1
• Synonyms: IL11RA1; interleukin 11 receptor, alpha chain 1; interleukin-11 receptor subunit alpha-1; NR-1; etl-2; locus 2; IL-11RA1; Il-11ra-alpha; IL-11R-alpha-1; IL-11R subunit alpha-1; novel cytokine receptor 1; enhancer trap locus homolog 2; IL-11 receptor subunit alpha-1; interleukin 11 receptor, alpha chain 2; NR1; GP130; Il11ra; Il-11ra; Il11ra2; AI314697
• Gene ID: 16157
• mRNA Refseq: NM_001163401
• Protein Refseq: NP_001156873
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem
• Function: cytokine receptor activity; interleukin-11 binding; interleukin-11 receptor activity; receptor activity