Rabbit Anti-Human Interleukin 1 Receptor-like 1 Monoclonal Antibody

• Cat.No.: CAB11565RH
• Product Overview: Rabbit Monoclonal Antibody to Human IL1RL1

Specification

• Species: Human
• Source: Rabbit
• Tag: Non
• Antigen Description: The protein IL1 RL1, also known as T1, ST2, is a member of the interleukin-1 receptor family with a soluble secreted form (sST2) and a transmembrane form (ST2L). The coding gene forms a cytokine receptor gene cluster together with IL1R1(interleukin 1 receptor, type I), IL1R2(interleukin 1 receptor, type I I) and IL1RL2(interleukin 1 receptor-like 2) genes in a region mapped to chromosome 2q12. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of the protein IL1RL1 and induces production of Th2 cytokines.
• Specificity: Human IL1RL1 / IL1R4. No cross-reactivity in ELISA with Human IL1R1, Human IL1R2, Human IL1RA, Human cell lysate (293 cell line)
• Immunogen: Recombinant Human IL1RL1 / IL1R4 Protein
• Isotype: Rabbit IgG
• Cross Reactivity: 003
• Clone: A004
• Applications: WB; ELISA
• Dilution: Western blot: This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human IL1R4 in WB.Using a DAB detection system, the detection limit for Human IL1R4 is approximately 1 ng/lane under non-reducing conditions and 0.125 ng/lane under reducing conditions.Direct ELISA: This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human IL1R4. The detection limit for Human IL1R4 is approximately 0.00245 ng/well.
• Preparation: This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Human IL1RL1 / IL1R4 ( rh IL1RL1 / IL1R4; Met 1 - Phe 328; NP_003847.2)
• Format: 0.2 μm filtered solution in PBS with 5% trehalose
• Storage: This antibody can be stored at 2-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: IL1RL1 interleukin 1 receptor-like 1 [ Homo sapiens ]
• Official Symbol: IL1RL1
• Synonyms: IL1RL1; interleukin 1 receptor-like 1; interleukin-1 receptor-like 1; DER4; FIT 1; homolog of mouse growth stimulation expressed; IL33R; ST2; ST2L; ST2V; T1; growth stimulation-expressed; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed; FIT-1; MGC32623
• Gene ID: 9173
• mRNA Refseq: NM_003856
• Protein Refseq: NP_003847
• MIM: 601203
• UniProt ID: Q01638
• Chromosome Location: 2q12
• Function: cytokine receptor activity; interleukin-1 receptor activity; interleukin-33 binding; protein binding; receptor activity; receptor signaling protein activity