Native Peanut Arachis hypogaea Lectin (PNA)

• Cat.No.: PNA-586P
• Product Overview: Native Peanut Arachis hypogaea Lectin (PNA) - Pure
  Blood Group Specificity: T antigen (M, N)
  Preferred Sugar Specificity: Galβ3GalNAc
  Inhibiting or Eluting Sugar: Galactose
  Divalent Ions: Ca++, Mg++
  Mitogenic Activity: No
  Hazardous Shipping: Non-hazardous

Specification

• Description: Arachis hypogaea agglutinin (PNA) is purified by affinity chromatography and is consisting of four subunits of approximately 27,000 each. This lectin has an isoelectric point between pH 5. 5 and pH 6. 5. It has a carbohydrate specificity for Galβ3GalNAc with an eluting sugar of galactose. Galactose and lactose are poor inhibitors while disaccharide Gal β(1->3)GalNAc and desialylated human erythrocyte N-substance (T-antigen which is present in many M and N blood groups) are potent inhibitors of PNA.
  Although extracts of Arachis hypogaea do not agglutinate untreated or trypsin-treated human erythrocytes, PNA has been known to agglutinate neuraminidase-treated human red blood cells. PNA may be used for clinical determination of T-polyagglutinability of erythrocytes and probing cell membranes of normal and malignant cells. This lectin can be of use in characterization of tumor-specific antigens on the surface of malignant cells. It can be employed in the fractionation of stem cells in mice for use in bone marrow transplantation across histocompatibility barriers.
• Source: Peanut
• Species: Peanut
• Form: Lyophilized
• Molecular Mass: 110 kDa
• Purity: Affinity purified
• Applications: Cancer biomarker, Histochemistry and IHC, Human erythrocyte/lymphocyte studies
• Storage: At -20 centigrade.

Gene Information

• Official Symbol: PNA
• Synonyms: Arachis hypogaea Lectin; PNA