Native Human VTN

• Cat.No.: VTN-31736TH
• Product Overview: Full length Vitronectin purified from Human plasma, MWt 75 kDa.

Specification

• Species: Human
• Tag: Non
• Description: The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond.
• Tissue specificity: Plasma.
• Biological activity: Second order rate constants for inhibition of:uPA = 6.3 x 106 M-1s-1tPA = 5.7 x 106 M-1s-1
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50mM Sodium phosphate, 100mM Sodium chloride, pH 7.4
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Contains 4 hemopexin-like domains.Contains 1 SMB (somatomedin-B) domain.
• Full Length: Full L.

Gene Information

• Gene Name: VTN vitronectin [ Homo sapiens ]
• Official Symbol: VTN
• Synonyms: VTN; vitronectin; vitronectin (serum spreading factor, somatomedin B, complement S protein); complement S protein; serum spreading factor; somatomedin B; VN
• Gene ID: 7448
• mRNA Refseq: NM_000638
• Protein Refseq: NP_000629
• MIM: 193190
• Uniprot ID: P04004
• Chromosome Location: 17q11.2
• Pathway: ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; FOXA1 transcription factor network, organism-specific biosystem; Focal Adhesion, organism-specific biosystem; Focal adhesion, organism-specific biosystem
• Function: extracellular matrix binding; heparin binding; integrin binding; polysaccharide binding; scavenger receptor activity