Native Human PLG

• Cat.No.: PLG-30083TH
• Product Overview: Full length Human Plasminogen mature protein purified from human plasma.

Specification

• Description: The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.
• Tissue specificity: Present in plasma and many other extracellular fluids. It is synthesized in the liver.
• Biological activity: Activity: >120 units per mg protein.One unit is defined as the amount of enzyme, which will hydrolyze 1 micromole of N-tosyl-L-arginine ester in 30 minutes at 37°C at pH 8.0.
• Form: Lyophilised:Reconstitute with 467ul distilled water.
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20mM Tris, 2mM EDTA, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the peptidase S1 family. Plasminogen subfamily.Contains 5 kringle domains.Contains 1 PAN domain.Contains 1 peptidase S1 domain.
• Tag: Non
• Full Length: Full L.

Gene Information

• Gene Name: PLG plasminogen [ Homo sapiens ]
• Official Symbol: PLG
• Synonyms: PLG; plasminogen
• Gene ID: 5340
• mRNA Refseq: NM_000301
• Protein Refseq: NP_000292
• MIM: 173350
• Uniprot ID: P00747
• Chromosome Location: 6q26
• Pathway: Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem
• Function: apolipoprotein binding; cell surface binding; endopeptidase activity; peptidase activity; protein binding