Native Gorse Ulex europaeus Lectin (UEA II)

• Cat.No.: UEA II-738G
• Product Overview: Native Gorse Ulex europaeus Lectin (UEA II) - Pure
  Blood Group Specificity: O>A3
  Preferred Sugar Specificity: Oligomers of β(1,4) - linked N-Acetylglucosamine
  Inhibiting or Eluting Sugar: GlcNAc β(1,4) GlcNAc
  Divalent Ions: Ca++, Mn++, Zn++
  Hazardous Shipping: Non-hazardous
  Appearance Color: White to off-white

Specification

• Description: Affinity purified Ulex europaeus agglutinin (UEA II) is isolated from gorse seeds and separated from crude extract. This lectin is a glycoprotein that consists of four 24,000 Da monomer subunits that require Ca2+ for binding to its ligands through carbohydrate recognition domain. It is specific for di-N-acetylchitobiose, an oligomer of GlcNAc. The monosaccharide GlcNAc is not an inhibitor of the lectin activity. UEA II has no mitogenic activity and agglutinates type O erythrocytes with greater interest than type A3 erythrocytes. Addition of EDTA eliminates agglutinating activity. Agglutinating activity can be recovered with the addition of calcium. UEA II is a potent inhibitor of the lectin complement pathway following endothelial oxidative stress. The molecular mechanism of UEA II-induced inhibition of the lectin complement pathway appears to be through competition for a common binding site on the endothelial cell and not at the level of mannose-binding lectin (MBL) inhibition.
• Source: Gorse
• Species: Gorse
• Form: Lyophilized Powder
• Molecular Mass: 96 kDa
• Purity: Affinity purified
• Storage: At -20 centigrade.

Gene Information

• Official Symbol: UEA II
• Synonyms: Ulex europaeus Lectin; UEA II