Matrix Metalloproteinase-2 (MMP-2) fluorometric drug discovery Kit

• Cat.No.: Kit-0577
• Product Overview: A QuantiZyme Assay System. The MMP-2 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-2 (MMP-2, gelatinase A) using a quenched fluorogenic peptide: OMNIMMP fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH. Mca fluorescence is quenched by the Dpa group until cleavage by MMPs at the Gly-Leu bond separates the two moieties. The assays are performed in a convenient 96-well microplate format. The kit is useful to screen inhibitors of MMP-2, a potential therapeutic target. Included are active enzyme, assay buffer, a prototypic control inhibitor (NNGH3), and a detailed instruction booklet.

Specification

• Size: 96 wells
• Applications: Fluorescence microscopy, HTS
• Storage: -80°C
• Kit Components: MMP-2 enzyme (human) (recombinant), substrate, calibration standard, inhibitor, assay buffer, 96-well white microplate.
• Tag: Non