Lysine-specific histone demethylase1 with REST corepressor1

• Cat.No.: CBCRY04

Specification

• Cat. No.: CBCRY04
• Background: Histone modifications, such as acetylation and methylation, are important epigenetic marks that regulate diverse biological processes that use chromatin as the template, including transcription. Dysregulation of histone acetylation and methylation leads to the silencing of tumor suppressor genes and contributes to cancer progression. Inhibitors of enzymes that catalyze the addition and removal of these epigenetic marks thus have therapeutic potential for treating cancer. Lysine-specific demethylase 1 (LSD1) is the first discovered histone lysine demethylase and, with the help of its cofactor CoREST, specifically demethylates mono- and dimethylated histone H3 lysine 4 (H3-K4), thus repressing transcription.
• Protein Classification: Oxidoreductase/repressor
• Structure Weight: 101692.78 Da
• Polymer: 1
• Molecule: Lysine-specific Histone Demethylase 1
• Chain Length: 666 amino acids
• PDB ID: 2UXX
• MMDB ID: 59741
• Source: E.coli
• Method: X-Ray Diffraction
• Resolution: 2.74Å
• Ligand Chemical Component: chloride ion, FA9, glycerol
• Reference: Yang, M., Culhane, J.C., Szewczuk, L.M., Jalili, P., Ball, H.L., Machius, M., Cole, P.A., Yu, H.Structural Basis for the Inhibition of the Lsd1 Histone Demethylase by the Antidepressant Trans-2-Phenylcyclopropylamine.Biochemistry, 2007,46: 8058-8065
• Tag: Non

Gene Information

• Gene Name: KDM1
• Synonyms: RP1-184J9.1; AOF2; BHC110; KIAA0601; LSD1;BRAF35-HDAC complex protein BHC110; FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; amine oxidase (flavin containing) domain 2; lysine-specific histone demethylase 1; Flavin-containing amine oxidase domain-containing protein 2; lysine (K)-specific demethylase 1; EC 1.-.-.-; fad binding protein braf35 hdac complex 110 kda s; amine oxidase (flavin containing) domain 2
• UniProt ID: O60341
• Chromosome Location: 1p36.12
• Function: FAD binding; electron carrier activity; oxidoreductase activity; transcription factor activity; transcription factor binding
• Gene ID: 23186