Human Myelin basic protein

• Cat.No.: MBP-6947H
• Product Overview: Human Myelinbasic protein, was highly Purified from human brain by method of Määttä etal.

Specification

• Species: Human
• Source: Human Brain
• Tag: Non
• Description: MBP is a peripheralmembrane protein, and its interaction with lipids is generally believed to becritical for the formation and stability of the multilamellar myelin sheath.It has been identified as a Ca2+-calmodulin regulated agent foractin polymerization, tropomyosin and actomyosin function, tubulinstabilization, and clathrin assembley. MBP is generally considered to be theantigen responsible for autoimmunity in multiple sclerosis (MS) and it hasthe capability to induce experimental allergic encephalomyelitis (EAE). MBPis also an endogenous inhibitor of the high-affinity cannabinoid binding sitein the brain and a substrate for numerous protein kinases (MAPK,serine/threonine kinase, protein kinase C). MBP is also suggested to beinvolved in intracellular signalling and as cytoskeletal components.
• Concentration: 1mg/mlafter reconstitution
• Appearance: White tooff-white powder.
• Formulation: Lyophilized. Essentially salt-free.
• Purity: >95%(SDS-PAGE; Immunoblot)
• Reconstitution: Reconstitutewith distilled water
• Application: Can be used toinduce relapsing experimental autoimmune encephalomyelitis in animals. Thisproduct may also be used as a substrate for protein kinases.
• Storage: Stable for at least1 year when stored at +4°C. Reconstituted protein is stable for at least sixmonths at -20°C and for at least 24 hours at +37°C in aqueous solution.

Gene Information

• Gene Name: MBP myelin basicprotein [ Homo sapiens ]
• Synonyms: myelinbasic protein; MGC99675; MBP; Golli-MBP; myelin A1 protein; myelin membraneencephalitogenic protein;OTTHUMP00000163776; OTTHUMP00000174387;OTTHUMP00000174388
• Gene ID: 4155
• mRNA Refseq: NM_001025081
• Protein Refseq: NP_001020252
• MIM: 159430
• UniProt ID: P02686
• Chromosome Location: 18q23
• Function: structuralconstituent of myelin sheath