Dynein Light Chain Dnlc2a

• Cat.No.: CBCRY31

Specification

• Source: E.coli
• Tag: Non
• Background: The human light chain of the motor protein dynein, Dnlc2A, is also a novel TGF-beta-signaling component, which is altered with high frequency in epithelial ovarian cancer. It is an important mediator of dynein and the development of cancer, owing to its ability to bind to the dynein intermediate light chain (DIC) IC74 and to regulate TGF-beta-dependent transcriptional events.
• Protein Classification: Transport Protein
• Structure Weight: 24324.71 Da
• Polymer: 1
• Molecule: Dynein light chain 2A, cytoplasmic
• Chain Length: 106 amino acids
• PDB ID: 2HZ5
• MMDB ID: 53434
• Method: X-Ray Diffraction
• Resolution: 2.10Å
• Ligand Chemical Component: Cesium ion
• Reference: Liu, J.-F., Wang, Z.-X., Wang, X.-Q., Tang, Q., An, X.-M., Gui, L.-L., Liang, D.-C. (2006) Crystal structure of human dynein light chain Dnlc2A: Structural insights into the interaction with IC74 Biochem.Biophys.Res.Commun. 349: 1125-1129

Gene Information

• Gene Name: DYNLRB1
• Synonyms: BITH; BLP; DNCL2A; DNLC2A; ROBLD1; OTTHUMP00000030691; ROBL/LC7-like 1; Roadblock-1; bithoraxoid-like protein; cytoplasmic dynein light chain 2A; dynein, cytoplasmic, light polypeptide 2A; dynein-associated protein HKM23; dynein-associated protein Km23; roadblock domain containing 1
• UniProt ID: Q9NP97
• Gene ID: 83658
• Chromosome Location: 20q11.21
• Function: microtubule motor activity; protein binding