Recombinant Human Bone Morphogenetic Protein Receptor, Type II, GST-tagged

• Cat.No.: BMPR2-993H
• Product Overview: Recombinant human BMPR2 (174-end) was expressed using baculovirus in Sf9 insect cells using an N-terminal His tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: His
• Protein Length: 174-end a.a.
• Description: BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs that are involved in endochondral bone formation and embryogenesis. The loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to the pathogenesis of primary pulmonary hypertension (PPH) and BMPR2 also plays an essential role in human T-cell differentiation.
• Applications: Kinase Assay; Western Blot
• Molecular Weight: 115 kDa
• Expression System: Sf9 insect cells using baculovirus
• Form: Recombinant protein stored in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25 % glycerol.
• Specific Activity: 14 nmol/min/mg
• Purity: > 75 %
• Concentration: 0.1 ug/ul
• Sequences: 174-end
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: ALK1 signaling events; ALK2 signaling events; BMP receptor signaling; BMP signalling and regulation; Cytokine-cytokine receptor interaction; Heart Development; Id Signaling Pathway; TGF-beta signaling pathway; Signaling by BMP

Gene Information

• Gene Name: BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) [ Homo sapiens ]
• Official Symbol: BMPR2
• Synonyms: BMPR2; bone morphogenetic protein receptor, type II (serine/threonine kinase); BMR2; PPH1; BMPR3; BRK-3; T-ALK; BMPR-II; FLJ41585; FLJ76945; bone morphogenetic protein receptor type-2; BMPR-2; BMP type-2 receptor; BMP type II receptor; type II activin receptor-like kinase; bone morphogenetic protein receptor type II; type II receptor for bone morphogenetic protein-4; OTTHUMP00000164984; OTTHUMP00000164985
• Gene ID: 659
• mRNA Refseq: NM_001204
• Protein Refseq: NP_001195
• MIM: 600799
• UniProt ID: Q13873
• Chromosome Location: 2q33-q34
• Function: ATP binding; activin receptor activity, type II; metal ion binding; nucleotide binding; protein binding; receptor activity; transforming growth factor beta receptor activity; transmembrane receptor protein serine/threonine kinase activity