Recombinant Human Bone Morphogenetic Protein Receptor, Type IB, GST-tagged

• Cat.No.: BMPR1B-992H
• Product Overview: Recombinant human BMPR1B (149-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 149-end a.a.
• Description: BMPR1B (also known as ALK6) is a member of the transmembrane serine/threonine kinase that is the member of the bone morphogenetic protein (BMP) receptor, which is closely related to the activin receptors, ACVR1 and ACVR2. ALK6 is mainly involved in the endochondral bone formation and embryogenesis. ALK6 expressed in normal and cancerous prostate tissues and used in the endocrine therapy that given to the prostate cancer patients. BMPR1B receptor trafficking also play a significant role in FOP pathogenesis and used in human T-cell differentiation.
• Applications: Kinase Assay; Western Blot
• Molecular Weight: 68 kDa
• Expression System: Sf9 insect cells using baculovirus
• Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
• Specific Activity: 23 nmol/min/mg
• Purity: > 85 %
• Concentration: 0.1 ug/ul
• Sequences: 149-end
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: Cytokine-cytokine receptor interaction; TGF-beta signaling pathway; Signaling by BMP; Ovarian Infertility Genes

Gene Information

• Gene Name: BMPR1B bone morphogenetic protein receptor, type IB [ Homo sapiens ]
• Official Symbol: BMPR1B
• Synonyms: BMPR1B; bone morphogenetic protein receptor, type IB; ALK6; ALK-6; CDw293; bone morphogenetic protein receptor type-1B; BMPR-1B; BMP type-1B receptor; activin receptor-like kinase 6; serine/threonine receptor kinase; Bone morphogenetic protein receptor type-1B; BMP type-1B receptor; BMPR-1B; EC 2.7.11.30; OTTHUMP00000161621; OTTHUMP00000161622; OTTHUMP00000219359; OTTHUMP00000219880; OTTHUMP00000219882
• Gene ID: 658
• mRNA Refseq: NM_001203
• Protein Refseq: NP_001194
• MIM: 603248
• UniProt ID: O00238
• Chromosome Location: 4q23-q24
• Function: ATP binding; SMAD binding; activin receptor activity, type II; metal ion binding; nucleotide binding; protein serine/threonine kinase activity; receptor activity; receptor signaling protein serine/threonine kinase activity; transforming growth factor beta receptor activity; transmembrane receptor protein serine/threonine kinase activity