Human Clusterin

• Cat.No.: CLU-3661H
• Product Overview: Native protein purified from human plasma.

Specification

• Species: Human
• Tag: Non
• Description: Clusterin is a 75-80 kDa disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apoptosis. In humans, clusterin is encoded by the CLU gene.
• Form: Filtered (0,4 μm) and lyophilized from PBS, pH 7.5.
• Research topic: Others; Renal disease; Sepsis
• Purity: >95%
• Reconstitution: Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely.
• Applications: ELISA; Western blotting
• Quality Control Test: BCA to determine quantity of the protein; SDS-PAGE to determine purity of the protein
• Storage: Store lyophilized protein at -20°C. Lyophilized protein remains stable until the expiry date when stored at -20°C. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at -80°C for long term storage. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after one week at 4°C.
• Publications:
  Clusterin and complement activation in exfoliation glaucoma (2014)

Gene Information

• Gene Name: CLU clusterin [ Homo sapiens ]
• Official Symbol: CLU
• Synonyms: CLU; clusterin; CLI; AAG4; APOJ; KUB1; SGP2; SGP-2; SP-40; TRPM2; TRPM-2; MGC24903; apo-J; NA1/NA2; apolipoprotein J; OTTHUMP00000128311; OTTHUMP00000225247; OTTHUMP00000225248; OTTHUMP00000225249; ku70-binding protein 1; sulfated glycoprotein 2; aging-associated protein 4; complement lysis inhibitor; complement cytolysis inhibitor; complement-associated protein SP-40,40; testosterone-repressed prostate message 2
• Gene ID: 1191
• mRNA Refseq: NM_203339
• Protein Refseq: NP_976084
• MIM: 185430
• UniProt ID: P10909
• Chromosome Location: 8p21-p12
• Pathway: Formation of Platelet plug; Hemostasis; Platelet Activation; Platelet degranulation; Response to elevated platelet cytosolic Ca2+; Validated targets of C-MYC transcriptional repression
• Function: NOT ATPase activity; misfolded protein binding; ubiquitin protein ligase binding; ubiquitin protein ligase binding