Bovine Myelin basic protein, Biotin-Conjugated
Cat.No. : | MBP-6949B |
Product Overview : | Bovine Myelinbasic protein, biotin-conjugated, was highly Purifiedfrom bovine central nervous system tissue by method of Määttä et al. |
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Species : | Bovine |
Source : | Bovine Central Nervous System Tissue |
Tag : | Non |
Description : | MBP is a peripheralmembrane protein, and its interaction with lipids is generally believed to becritical for the formation and stability of the multilamellar myelin sheath.It has been identified as a Ca2+-calmodulin regulated agent foractin polymerization, tropomyosin and actomyosin function, tubulinstabilization, and clathrin assembley. MBP is generally considered to be theantigen responsible for autoimmunity in multiple sclerosis (MS) and it hasthe capability to induce experimental allergic encephalomyelitis (EAE). MBPis also an endogenous inhibitor of the high-affinity cannabinoid binding sitein the brain and a substrate for numerous protein kinases (MAPK,serine/threonine kinase, protein kinase C). MBP is also suggested to beinvolved in intracellular signalling and as cytoskeletal components. |
Purity : | ≥95% (SDS-PAGE; immunoblot) |
Formulation : | Lyophilized. Essentially salt-free. |
Reconstitution : | Reconstitute with distilled water. |
Application : | Substratefor various kinases including MAPK, PKA, calmodulin-dependent protein kinase,PKC and phosphorylase kinase. Raf1, MEK, and MEKK can also use MBP as asubstrate. The biotinyl moiety allow this substrate to be used in conjunctionwith a streptavidin membrane in kinase assays. |
Storage : | Stablefor at least 1 year when stored at +4°C. Reconstituted protein is stable forat least 6 months at -20°C and for at least 24 hours at +37°C in aqueoussolution. |
Gene Name | MBP myelin basic protein [ Bostaurus ] |
Official Symbol | MBP |
Synonyms | MBP;myelin basic protein; myelin A1 protein; microtubule-stabilizing protein; 20kDa microtubule-stabilizing protein |
Gene ID | 618684 |
mRNA Refseq | NM_001206674 |
Protein Refseq | NP_001193603 |
Chromosome Location | 24q11-q13.2 |
Function | structuralconstituent of myelin sheath |
◆ Recombinant Proteins | ||
MBP-6947H | Human Myelin basic protein | +Inquiry |
MBP-4513H | Recombinant Human MBP Protein (Met1-Lys192), N-His tagged | +Inquiry |
MBP-2764H | Recombinant Human MBP protein, His & GST-tagged | +Inquiry |
MBP-2755P | Recombinant Pan-species (General) MBP Protein, His/MBP-tagged | +Inquiry |
MBP-50P | Recombinant Pig MBP protein, His-tagged | +Inquiry |
◆ Native Proteins | ||
MBP-89S | Native Swine MBP Protein | +Inquiry |
MBP-6949M | Native Mouse Myelin basic protein | +Inquiry |
MBP-99S | Native Swine MBP | +Inquiry |
◆ Cell & Tissue Lysates | ||
MBP-4436HCL | Recombinant Human MBP 293 Cell Lysate | +Inquiry |
MBP-4437HCL | Recombinant Human MBP 293 Cell Lysate | +Inquiry |
MBP-4438HCL | Recombinant Human MBP 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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